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Change the Brain; Relieve the Pain; Transform the Person

This animation shows local cells activating pain nerve endings. These send electrical signals to the spinal cord and brain, making and releasing Substance-P at nerve endings and back out to the area of injury. At nerve endings the pain map expands and more local nerve cells are recruited to transmit more pain. Meanwhile 80% of the manufactured Substance-P is sent back out to the injury site. There, along with other inflammatory substances, touch receptors in skin are recruited to send signals to incoming nerve cells, which go through a genetic change and make Substance-P. This is released at nerve terminals further spreading out the pain signal. Now nerves that do not normally transmit pain, also send pain signals to the brain. When nerves themselves are injured, a massive amount of Substance-P is release at nerve terminals.
© 2012 Michael Moskowitz, Marla Golden Contact