Anandamide is a fast acting molecule present in both the brain and the peripheral body. It has anti-inflammatory, analgesic and pleasure properties, but also modifies broad categories of brain responses throughout sensory and motor circuits. It helps with sleep, appetite regulation, anxiety, anti-cancer cell spread, hormone regulation, brain neuroplasticity and emotional regulation. It is very quick to act and very quick to being broken down. When nerve cells in the pain circuits of the brain fire continuously, the local activation of astrocytes and microglia, creates and ongoing inflammatory response that keeps this runaway firing going. Anandamide shuts this off by filling receptors on the membranes of microglia, starting an anti-inflammatory cascade that quiets everything back down to normal.